Peer-Reviewed Publications:

Zhulyn O, Rosenblatt HD, Shokat L, Dai S, Kuzuoglu-Öztürk D, Zhang Z, Ruggero D, Shokat KM, Barna M. Evolutionarily divergent mTOR remodels translatome for tissue regeneration. Nature. 2023. DOI:10.1038/s41586-023-06365-1

Xu AF, Molinuevo R, Fazzari E, Tom H, Zhang Z, Menendez J, Casey KM, Ruggero D, Hinck L, Pritchard JK, Barna M. Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebratesElife. 2023. DOI:10.7554/eLife.78695

+Kuzuoglu-Ozturk D, +Aksoy O, Schmidt C, Lea R, Larson JD, Phelps RRL, Nasholm N, Holt M, Contreras A, Huang M, Wong-Michalak S, Shao H, Wechsler-Reya R, Phillips JJ, Gestwicki JE, *Ruggero D, *Weiss WA. N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in MedulloblastomaCancer Res. 2023. DOI:10.1158/0008-5472.CAN-22-0945 + =co-first author, DK (Ruggero lab). * =co-corresponding authors

*Forester CM, Oses-Prieto JA, Phillips NJ, Miglani S, Pang X, Byeon GW, DeMarco R, Burlingame A, Barna M, *Ruggero D. Regulation of eIF4E guides a unique translational program to control erythroid maturation. Sci Adv. 2022. DOI:10.1126/sciadv.add3942.CAN-22-0945 *=co-corresponding authors

Wang HY, Yang H, Holm M, Tom H, Oltion K, Al-Khdhairawi AAQ, Weber JF, Blanchard SC, Ruggero D, Taunton J. Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3Nat Chem. 2022. DOI:10.1038/s41557-022-01039-3

*Kovalski JR, *Kuzuoglu-Ozturk D, *Ruggero D. Protein synthesis control in cancer: selectivity and therapeutic targetingEMBO J. 2022. DOI:10.15252/embj.2021109823  * =co-corresponding authors

Barna M, Karbstein K, Tollervey D, Ruggero D, Brar G, Greer EL, Dinman JD. The promises and pitfalls of specialized ribosomesMol Cell. 2022. DOI:10.1016/j.molcel.2022.05.035

Xu Y, Ruggero D. A tRF nucleator for Nucleolin in cancer metastasisMol Cell. 2022. DOI:10.1016/j.molcel.2022.06.025

Liedmann S, Liu X, Guy CS, Crawford JC, Rodriguez DA, Kuzuoğlu-Öztürk D, Guo Ao, Verbist KC, Temirov J, Chen MJ, Ruggero D, Zhang H, Thomas PG, Green DR. Localization of a TORC1-eIF4F translation complex during CD8 + T cell activation drives divergent cell fateMol Cell. 2022. DOI:10.1016/j.molcel.2022.04.016

Xu Y, Huangyang P, Wang Y, Xue L, Devericks E, Nguyen H, Yu X, Oses-Prieto JA, Burlingame AL, Miglani S, Goodarzi H, and Ruggero D. ERα is an RNA-binding protein sustaining tumor cell survival and drug resistanceCell. 2021. DOI:10.1016/j.cell.2021.08.036

Schmidt C, Navickas A, Zindy F, Farmer D, Ruggero D, Goodarzi H, Roussel MF, Schwer B, and William Weiss. OMIC-03. Translational Control in MYC and MYCN MedulloblastomaNeuro-Oncology. 2021. DOI:10.1093/neuonc/noab090.150

Kovalski J.R., Xu Y., Ruggero D. Examining Myc-dependent translation changes in cellular homeostasis and cancer. The Myc Gene. Methods in Molecular Biology. 2021. DOI: 10.1007/978-1-0716-1476-1_13

Forester C., Ruggero D. Releasing the brake on protein synthesis in hematopoietic stem cellsCell Stem Cell. 2021. DOI: 10.1016/j.stem.2021.06.003

Tiu G. C., Kerr C. H., Forester C. M., Krishnarao P. S., Rosenblatt H. D., Raj N. Lantz T.C., Zhulyn O., Bowen ME., Shokat L., Attardi LD., Ruggero D.,* & Barna M.* (2021). A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathiesDevelopmental Cell. 2021. DOI: 10.1016/j.devcel.2021.06.013 *Co-correspondent

Kuzuoglu-Öztürk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, and Ruggero D. Revealing new molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Cell Reports. 2021. DOI: 10.1016/j.celrep.2021.109321

Chiu H., Buono R., Jackson L. V., Herzog L. O., Mallya S., Conn C. S., Ruggero D. & Fruman, D. A. (2021). Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte functioniScience. 2021. DOI: 10.1016/j.isci.2021.102748

Conn C*, Yang H*,**, Tom H, Ikeda K, Oses-Prieto J, Vu H, Oguri Y, Nair S, Gill R, Kajimura S, DeBerardinis R, Burlingame A, and Ruggero D*. The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesityNature Metabolism. 2021. DOI: 10.1038/s42255-021-00349-z *=co-first authors **=co-corresponding authors. 

Zhao N, Huang Y, Wang YH, Muir K, Chen, YC, Hooshdaran N, Wei J, Viswanath P, Seo Y, Ruggero D, Renslo AR, Evans MJ. Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer TherapiesJournal of Nuclear Medicine. 2020. DOI:

Wei J, Wang YH, Lee CY, Truillet C, Oh DY, Xu Y, Ruggero D, Flavell RR, VanBrocklin HF, Seo Y, Craik CS, Fong L, Wang CI, and Evans MJ. An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers. Molecular imaging and biology. 2020. DOI: 10.1007/s11307-020-01527-3

Xu Y, Ruggero D. The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications. Annual Review of Cancer Biology. 2020. DOI: 10.1146/annurev-cancerbio-030419-033420

Gordon DE…, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. A SARS-CoV-2 protein interaction map reveals targets for drug repurposingNature. 2020, DOI: 10.1101/2020.03.22.002386.

Wei J, Leung K, Truillet C, Ruggero D, Wells J, & Evans MJ. Profiling the surfaceome identifies therapeutic targets for cells with hyperactive mTORC1 signaling. Molecular & Cellular Proteomics, 2019. DOI: 10.1074/mcp.RA119.001785.

McMahon M, Contreras A, Holm M, Uechi T, Forester CM, Pang X, Jackson C, Calvert ME, Chen B, Quigly DA, Luk JM, Kelley RK, Gordan JD, GIll RM, Blanchard SC, Ruggero, DA single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RASeLife. 2019, 8, doi: 10.7554/eLife.48847.

Robichaud N, Sonenberg N, Ruggero D, and Schneider RJ. Translational Control in CancerCold Spring Harbor Perspectives Biology. 2019 Jul 1;11(7), doi: 10.1101/cshperspect.a032896. 

Tameire F, Verginadis I, Leli N, Czech A, von Kleeck R, Polte C, Conn CS, Monroy M, Fu W, Wang P, Kossenkov A, Ignatova Z, Ruggero D, and Koumenis C. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progressionNature Cell Biology. 2019 Jul;21(7), 889-899, doi: 10.1038/s41556-019-0347-9.

Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H. Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and DecayMol Cell. 2019 Jun 25, doi: 10.1016/j.molcel.2019.06.001.

Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ. Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography. ACS Cent Sci. 2019 Apr 24;5(4):727-736, doi: 10.1021/acscentsci.9b00240.

Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, and Mukherjee S. A Legionella pneumophila kinase phosphorylates the Hsp70 chaperone family to inhibit eukaryotic protein synthesisCell Host & Microbe. Epub 2019.   

Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland S, Asthana S, Barna M, Webster KR, Cunningham JT, and Ruggero DTranslation control of the immune checkpoint in cancer and its therapeutic targetingNature Medicine, 2019, doi:10.1038/s41591-018-0321-2.

Chiu H, Jackson LV, Oh KI, Mai A, Ronai ZA, Ruggero D, Fruman DA. The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B LymphocytesJ Immunol. 2019 Jan 15;202(2):579-590, doi: 10.4049/jimmunol.1800602.

McMahon M, Ruggero DA Translation Tuning HuDdle for NeuronsMolecular Cell, vol. 71, no. 2, 2018, pp. 195–196, doi: 10.1016/j.chom.2019.01.006.

McMahon M, and Ruggero DA Wobbly Road to Drug Resistance in Melanoma: TRNA‐Modifying Enzymes in Translation ReprogrammingThe EMBO Journal, 2018, doi:10.15252/embj.201899978.

Nguyen HG*, Conn CS*,**, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Simko J, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D**. “Development of a Stress Response Therapy Targeting Aggressive Prostate Cancer.” Science Translational Medicine, vol. 10, no. 439, 2018, doi:10.1126/scitranslmed.aar2036. *=authors contributed equally to the manuscript; **=co-corresponding authors. 

Forester CM, Zhao Q, Phillips NJ, Urisman A, Challdey RJ, Oses-Prieto JA, Zhang L, Ruggero D*, Burlingame, A*. Revealing nascent proteomics in signaling pathways and cell differentiationPNAS, 2018 Mar 6; 115(10):2353-2358. *=co-corresponding authors

Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA. Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell. 2018 Jan. doi: 10.1016/j.ccell.2017.12.003.

Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018 Jan. doi: 10.1038/s41556-017-0006-y.

Ruggero D, Shaw RJ. Cell Regulation: 1000 Flavors including chocolate and chili peppers. Curr Opin Cell Biol. 2017 Apr. doi: 10.1016/

Truillet C, Cunningham JT, Parker MF, Huynh LT, Conn CS, Ruggero D, Lewis JS, Evans MJ. Non-invasive measurement of mTORC1 signaling with 89Zr-transferrin Clin Cancer Res. 2016 Dec 22. pii: clincanres.2448.2016. doi: 10.1158/1078-0432.CCR-16-2448. [Epub ahead of print]

So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA. The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytesSci Signal. 2016 May 31;9(430):ra57. doi: 10.1126/scisignal.aad8463.

Truitt ML, Ruggero DNew frontiers in translational control of the cancer genomeNat Rev Cancer. 2016 Apr 26;16(5):288-304. doi: 10.1038/nrc.2016.27.

Hsieh AC, Nguyen HG, Wen L, Edlind MP, Carroll PR, Kim W, Ruggero DCell type–specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors. Sci. Signal. 8, ra116 (2015).

Truitt ML*, Conn CS*, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero DDifferential Requirements for eIF4E Dose in Normal Development and Cancer. Cell, 2015 Jun 17. *=authors contributed equally to the manuscript

Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F. Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth ConditionsCancer Res. 2015 Jul 15; 75(14):2851-62.

Sheridan C, Grogan TR, Nguyen HG, Galet C, Rettig M, Hsieh AC, Ruggero DYB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence. Oncotarget. Advanced Online 2015 Mar 3.

Pelletier J, Graff J, Ruggero D, Sonenberg N. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Research, 2015 Jan 15;75(2):250-63.

McMahon M, Contreras A, Ruggero DSmall RNAs with big implications: New insights into H/ACA snoRNA function and their role in human disease. Wiley Interdisciplinary Reviews RNA, 2014 Oct 31.

Ruggero D, Shimamura A. Marrow failure: a window into ribosome biology. Blood. 2014 Oct 30;124(18):2784-92.

Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero DProtein and nucleotide biosynthesis are coupled through a single rate limiting enzyme, PRPS2, to drive cancer. Cell, 2014 May 22; 157(5):1088-1103.
Cancer Discovery 2014 July;4(7):757
Nature SciBX 2014 June 19:7(24)
Nature Reviews Cancer 2014 June 24:14(7):452
Faculty 1000

Barna M, Ruggero DTailor Made Protein Synthesis for HSCs. Cell Stem Cell, 2014 Apr 3;14(4):423-4.

Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Parallel measurement of dynamic changes in translation rates in single cells. Nature Methods, 2014 Jan;11(1):86-93.

Olshen AB, Hsieh AC, Stumpf CR, Olshen RA, Ruggero D, Taylor BS. Assessing gene-level translational control from ribosome profiling. Bioinformatics, 2013 Dec 1;29(23):2995-3002.

McMahon M, Bellodi C Ruggero D: The ‘fifth’ RNA nucleotide: A role for ribosomal RNA pseudouridylation in control of gene expression at the translational level. In: Biophysical approaches to translational control of gene expression. Dinman JD. (ed). Biophysics for the Life Sciences, Vol. 1. New York Heidelberg Dordrecht London: Springer, 2013. Print.

Cunningham JT, Ruggero DNew connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization. Cancer Discovery, 2013 Oct;3(10):1099-102. Review.

Stumpf CR, Moreno MV, Olshen AB, Taylor SB, Ruggero DThe translational landscape of the mammalian cell cycle. Molecular Cell, 2013 Nov 21;52(4):574-82.

Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero DMyc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A, 2013 Jul 16;110(29):11988-93.

Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero DH/ACA Small RNA Dysfunctions in Disease Reveal Key Roles for Noncoding RNA Modifications in Hematopoietic Stem Cell Differentiation. Cell Reports, 2013 May 30;3(5):1493-502.

Cunningham JT, Stumpf CR, Pourdehnad M, Ruggero DInvestigating Myc-dependent translational regulation in normal and cancer cells. In: Methods in Molecular Biology. Soucek L, Sodir N. (eds). New York: Humana Press, 2013. Print.

Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR. Common variable immunodeficiency as the initial presentation of dyskeratosis congenita. Journal of Allergy and Clinical Immunology, 2013 Feb 9;pii: S0091-6749(12)02640-1.

Santini E, Huynh TN, Pierre P, Kaphzan H*, Ruggero D*, Klann E. Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature, 2013 Jan 17;493(7432):411-5. *=equal contribution.
Nature Reviews Neuroscience February 2013;14(2):79.

Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature, 2013 Jan 17;493(7432):371-7.
Nature News and Comments, 21 November 2012 doi:10.1038/nature.2012.11869
Nature Reviews Drug Discovery January 2013;12(1):21
Nature Reviews Neuroscience February 2013;14(2):79
Frontiers in Cellular Neuroscience March 2013;7:28
Faculty 1000

Hart LS, Cunningham JT, Datta T, Lehman SL, Qiu B, Zhang H, Bi M, Liu H, Li C, Thomas-Tikhonenko A, Koong A, Fuchs SY, Diehl, JA, Ruggero D, Koumenis C. Endoplasmic Reticulum Stress-Mediated Autophagy Promotes Myc-Dependent Transformation and TumorigenesisJournal of Clinical Investigation, 2012 Dec 3;122(12):4621-34.
Science Daily 21 November 2012

Ruggero DRevisiting the nucleolus: from marker to dynamic integrator of cancer signaling. Science Signaling, 2012 Sep 11;5(241):pe38. Review.

Upton JP, Wang L, Han D, Wang ES, Huskey N, Lim L, Truitt M, McManus T, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science, 2012 Nov 9;338(6108):818-22.
Developmental Cell, 13 November 2012;23(5):921-3
Faculty 1000

McMahon M, Bellodi C, Ruggero D. rRNA Modification and Pseudouridylation. Biophysical Approaches to Translational Control of Gene Expression. Springer Press, 2012.

Ruggero, DTranslational Control in Cancer Etiology. Cold Spring Harb Perspect Biol. Cold Spring Harbor Laboratory Press, 2012.

Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero DThe translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 2012 Feb 22;485(7396):55-61.
Nature 2012 May 3;485(7396):50-1
Cell 149(5): 955, 2012
Cancer Discovery April 2012 2; 297
Nature Reviews Genetics 13, 223 (April 2012)
Cell Research advance online publication 29 May 2012
Cancer Research published online 15 June 2012
Faculty 1000

Bellodi C*, Jack K, Niederer R*, Landry DM, Meskauskas A, Musalgaonkar S, Kopmar N, Krasnykh O, Dean AM, Thompson SR, Ruggero D**, and Dinman JD**. rRNA Pseudouridylation Defects Affect Ribosomal Ligand Binding and Translational Fidelity from Yeast to Human Cells. Molecular Cell 2011 Nov 18;44(4):660-6. *=These authors contributed equally to the manuscript, **=Corresponding authors.

Stumpf CR, Ruggero DThe Cancerous Translation Apparatus. Current Opinion in Genetics & Development 2011 Aug;21(4):474-83. Epub 2011 May 2.

Hsieh AC, Truitt ML, Ruggero DOncogenic AKTivation of Translation as a Therapeutic Target. British Journal of Cancer 2011 Jul 26;105(3):329-36.

Hsieh AC, Ruggero DTargeting eIF4E in CancerClinical Cancer Research 2010 Oct 15;16(20):4914-20. Epub 2010 Aug 11.

Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L, Ruggero DLoss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis. Cancer Res Jul 15;70(14):6026-35. Epub 2010 Jun 29.

Bellodi C, Kopmar N, Ruggero DDeregulations of p53 translational control in X-linked Dyskeratosis Congenita. EMBO J 2;29(11):1865-76, 2010.

Hsieh AC, Costa M, Zollo O, Davis C, Feldman M, Testa J, Meyuhas O, Shokat K, Ruggero D. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell 17(3):249-261, 2010.
Faculty 1000

Ruggero, DThe role of Myc-induced protein synthesis in cancer. Cancer Res 69(23):8839-43, 2009.

Feldman ME, Apsel B, Knight ZA, Ruggero D, Shokat K. Active-Site Inhibitors of mTOR Target Rapamycin Resistant Outputs of mTORC1 and mTORC2. PLOS Biol 7:e38, 2009.

Barna M, Pusic A, Zollo O, Costa M, Kondrashov N, Rego E, Rao P, Ruggero DSuppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature 456:971-5, 2008.
Nature Reviews Cancer 9:4-5, 2009
Faculty 1000

Yoon A, Peng G, Brandenburger Y, Zollo O, Xu W, Rego E, Ruggero D. Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science 312:902-906, 2006.
Faculty 1000

Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene 25:1974-1979, 2006.

Ruggero D, Sonenberg N. The Akt of translational control. Oncogene 24: 7426-7434, 2005.

Kaplan R, Riba R, Zacharoulis S, Jin D, Costa C, Vincent L, MacDonald D, Bramley A, Shido K, Kerns S, Ruggero D, Jensen KK, Shmelkov S, Hicklin, D, Port E, Port J, Altorki N, Rafii S, Lyden D. VEGFR1-positive hematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438:820-827, 2005.

Ruggero D, Montanaro L, Ma L, Xu W, Londei P, Cordon-Cardo C, Pandolfi PP. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nature Medicine 10:484-486, 2004.

Ruggero D and Pandolfi PP. Does the ribosome translate cancer? Nature Reviews Cancer 3:179-192, 2003.

Ruggero D, Grisendi S, Piazza F, Rego E, Mari F, Cordon-Cardo C, Pandolfi PP. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science 299:259-262, 2003.
Nature Genetics 33:116-7, 2003
Nature Reviews Cancer 3:87, 2003
Nature Medicine 9:172, 2003
Faculty 1000

Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Developmental Cell 3:499-510, 2002.

Ruggero D, Wang ZG, Pandolfi PP. The puzzling multiple lives of PML and its role in the genesis of cancer. Bioessays 22:827-835, 2000.

Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP. Promyelocytic Leukemia (PML) and Daxx participate in a novel nuclear pathway for apoptosis. Journal of Experimental Medicine 191:631-639, 2000.

Condó I, Ciammaruconi A, Benelli D, Ruggero D, Londei P. Cis-acting signals controlling translation initiation in the thermophilic archaeon Sulfolobus solfataricus. Molecular Microbiology 34:377-384, 1999.

Ruggero D, Wang ZG, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP. Pml is essential for multiple apoptotic pathways. First author shared. Nature Genetics 20:266-272, 1998.
Commentary in Nature Genetics 20:220-222, 1998.

Condó I, Ruggero D, Reinhardt R, Londei P. A novel aminopeptidase associated with the 60 kDa chaperonin in the thermophilic archaeon Sulfolobus solfataricus. Molecular Microbiology 29:775-786, 1998.

Ruggero D, Ciammaruconi A, Londei P. The chaperonin of the archaeon Sulfolobus solfataricus is an RNA-binding protein that participates in ribosomal RNA processing. EMBO Journal 17:3471-3477, 1998.

Ruggero D, Londei P. Differential antibiotic sensitivity determined by the large ribosomal subunit in thermophilic archaea. Journal of Bacteriology 178:3396-3398, 1996.

Ruggero D, Creti R, Londei P. In vitro translation of archaeal natural mRNAs at high temperatures. FEMS 107:89-94, 1993.

Book Chapters:

Kovalski J, Xu Y, Ruggero D. Investigating Myc-Dependent Translational regulation in Normal and Cancer Cells. In: Methods in Molecular Biology. In Press.

Nathaniel Robichaud, Davide Ruggero and Robert J. Schneider, Nahum Sonenberg: Translational control in cancer. In: Protein Synthesis and Translational Control. Hershey, JWB, Sonenberg N, Mathews MB. (eds). Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2018. Print.

Greene K, Li LC, Hsieh AC, Ruggero D, Carroll P: Molecular Basis of Prostate Cancer. In: Molecular Basis of Cancer. Mendelsohn J, Gray JW, Howley PM, Israel MA, Thompson CB (eds). Philadelphia: Elsevier (Saunders) Press, 2015. Print.

Tsukumo Y, Laplante M, Parsyan A, Ruggero D, Fonseca B: mTOR and Regulation of Translation. In: Translation and Its Regulation in Cancer Biology and Medicine. Parsyan A (ed). Dordrecht: Springer Science+Business Media, 2014. Print.

McMahon M, Bellodi C, Ruggero D: The ‘fifth’ RNA nucleotide: A role for ribosomal RNA pseudouridylation in control of gene expression at the translational level. In: Biophysical approaches to translational control of gene expression. Dinman JD. (ed). Biophysics for the Life Sciences, Vol. 1. New York Heidelberg Dordrecht London: Springer, 2013. Print.

Cunningham JT, Stumpf CR, Pourdehnad M, Ruggero D: Investigating Myc-dependent translational regulation in normal and cancer cells. In: Methods in Molecular Biology. Soucek L, Sodir N. (eds). New York: Humana Press, 2013. Print.

Ruggero D: Translational control in cancer etiology. In: Protein Synthesis and Translational Control. Hershey, JWB, Sonenberg N, Mathews MB. (eds). Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2013 Feb 1;5(2). Print.